{"id":4039,"date":"2023-04-18T13:39:00","date_gmt":"2023-04-18T13:39:00","guid":{"rendered":"https:\/\/kaqun.sk\/?p=4039"},"modified":"2023-04-18T13:39:00","modified_gmt":"2023-04-18T13:39:00","slug":"hypoxia-a-rakovina","status":"publish","type":"post","link":"https:\/\/www.kaqun.sk\/pl\/hypoxia-a-rakovina\/","title":{"rendered":"\u010co n\u00e1m zabudli poveda\u0165: Hypoxia najlep\u0161\u00ed priate\u013e rakoviny"},"content":{"rendered":"\n

Kysl\u00edk je nevyhnutn\u00fd pre ak\u00fdko\u013evek \u017eivot, preto\u017ee bez neho by nebolo mo\u017en\u00e9 existova\u0165. Celkovo je kysl\u00edk jedn\u00fdm z najroz\u0161\u00edrenej\u0161\u00edch prvkov na Zemi \u2013 predstavuje pribli\u017ene 46% hmotnosti zemskej k\u00f4ry (vr\u00e1tane kysl\u00edka v miner\u00e1loch) a v atmosf\u00e9re tvor\u00ed asi 21% objemu ako vo\u013en\u00fd plyn (O\u2082). V mest\u00e1ch alebo vo vy\u0161\u0161\u00edch nadmorsk\u00fdch v\u00fd\u0161kach je jeho koncentr\u00e1cia e\u0161te ni\u017e\u0161ia.<\/p>\n\n\n\n

\u013dudsk\u00e9 telo je vysoko aer\u00f3bny organizmus, ktor\u00fd potrebuje optim\u00e1lne prisp\u00f4sobenie pr\u00edsunu kysl\u00edka na \u00farove\u0148 tkan\u00edv, aby splnil metabolick\u00e9 n\u00e1roky<\/strong>. Tak ako n\u00e1\u0161 \u017eivot z\u00e1vis\u00ed od kysl\u00edka, aj kvalita n\u00e1\u0161ho zdravia a celkov\u00fd stav organizmu s\u00fa priamo ovplyvnen\u00e9 mno\u017estvom kysl\u00edka v tkaniv\u00e1ch, resp. parci\u00e1lnym tlakom kysl\u00edka v tkaniv\u00e1ch (pO2).<\/p>\n\n\n\n

Hypoxia postihne ka\u017ed\u00e9ho z n\u00e1s <\/h2>\n\n\n\n

S prib\u00fadaj\u00facim vekom kles\u00e1 mno\u017estvo kysl\u00edka v na\u0161ich tkaniv\u00e1ch (pozri graf). Dlhodob\u00fd nedostatok kysl\u00edka vedie k hypoxii, \u010do je stav, ktor\u00fd nie je v\u017edy zjavn\u00fd, a preto si ho mnoh\u00ed \u013eudia ani neuvedomuj\u00fa. <\/strong>Hypoxia sp\u00f4sobuje, \u017ee na\u0161e bunky nemaj\u00fa dostatok kysl\u00edka na produkciu energie, \u010do ovplyv\u0148uje v\u0161etky metabolick\u00e9 procesy v organizme.<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Horizont\u00e1lna os ukazuje n\u00e1\u0161 vek od 20 do 90 rokov a vertik\u00e1lna os ukazuje parci\u00e1lny tlak kysl\u00edka v na\u0161ich tkaniv\u00e1ch (pO2) v z\u00e1vislosti od veku. Priemern\u00fd zdrav\u00fd 30 – ro\u010dn\u00fd \u010dlovek m\u00e1 pO2<\/sub><\/sup> 93,7 mmHg<\/strong> a priemern\u00fd 50 – ro\u010dn\u00fd \u010dlovek u\u017e len 76,9 mmHg<\/strong> (modr\u00e1 krivka).<\/p>\n\n\n\n

<\/p>\n\n\n\n

Graf ukazuje hlavn\u00fd rozdiel medzi organizmom mlad\u00e9ho a star\u00e9ho \u010dloveka. Kv\u00f4li vy\u0161\u0161iemu parci\u00e1lnemu tlaku kysl\u00edka v tkaniv\u00e1ch<\/strong>, dok\u00e1\u017ee organizmus mlad\u00e9ho \u010dloveka r\u00fdchlej\u0161ie regenerova\u0165, m\u00e1 silnej\u0161iu obranyschopnos\u0165, m\u00e1 viac energie, v\u0161etky fyziologick\u00e9 procesy prebiehaj\u00fa efekt\u00edvne a bez probl\u00e9mov. <\/strong><\/p>\n\n\n\n

Ako vznik\u00e1 hypoxia<\/h2>\n\n\n\n

Hypoxia m\u00f4\u017ee postihn\u00fa\u0165 kohoko\u013evek, v akomko\u013evek veku z odli\u0161n\u00fdch d\u00f4vodov. Hypoxia m\u00f4\u017ee nasta\u0165 aj v pr\u00edpade dostato\u010dn\u00e9ho okysli\u010denia krvi. Hypoxiu sp\u00f4sobuje nedostatok kysl\u00edka vo vzduchu, zn\u00ed\u017eenie kapacity p\u013e\u00fac, zn\u00ed\u017eenie schopnosti krvi pren\u00e1\u0161a\u0165 kysl\u00edk do tkan\u00edv <\/strong>(an\u00e9mia, talasemia, ve\u013ek\u00e1 strata krvi, arteroskler\u00f3za), zn\u00ed\u017eenie schopnosti tkan\u00edv absorbova\u0165 kysl\u00edk <\/strong>(r\u00f4zne p\u013e\u00facne ochorenia), zn\u00ed\u017eenie schopnosti buniek vyu\u017e\u00edva\u0165 kysl\u00edk<\/strong> (otrava oxidom uho\u013enat\u00fdm, abnorm\u00e1lna funkcia mitochondri\u00ed) a nedostatok \u010derven\u00fdch krviniek<\/strong>.<\/p>\n\n\n\n

Ak na\u0161e bunky nemaj\u00fa dostatok kysl\u00edka, prest\u00e1vaj\u00fa spr\u00e1vne a efekt\u00edvne pracova\u0165 a nekontrolovane zomieraj\u00fa<\/strong>, \u010d\u00edm nar\u00fa\u0161a proces programovanej smrti buniek (apopt\u00f3za).<\/strong> Degener\u00e1cia buniek zr\u00fdch\u013euje proces starnutia organizmu a vedie k rozvoju degenerat\u00edvnych ochoren\u00ed. <\/strong><\/p>\n\n\n\n

O drahocenn\u00fd kysl\u00edk pripravujeme sami a ani o tom nevieme. Ka\u017edodenn\u00fd \u017eivotn\u00fd \u0161t\u00fdl, zl\u00e1 \u017eivotospr\u00e1va s nedostatkom vitam\u00ednov, miner\u00e1lov, dennej d\u00e1vky tekut\u00edn, nedostatok pohybu a ka\u017edodenn\u00fd stres s\u00fa faktorom, ktor\u00e9 n\u00e1s a na\u0161e bunky pripravuj\u00fa e\u0161te o v\u00e4\u010d\u0161ie mno\u017estvo kysl\u00edka (\u010derven\u00e1 krivka)<\/strong>.<\/p>\n\n\n\n

\u010co sp\u00f4sobuje hypoxia?<\/strong><\/h2>\n\n\n\n

Hypoxia sp\u00f4sobuje v tkaniv\u00e1ch spomalenie \u010di \u00faplne zastavenie procesov regener\u00e1cie, lie\u010dby a hojenia r\u00e1n, u\u013eah\u010duje \u0161\u00edrenie chor\u00f4b v organizme a vo ve\u013ekom sa produkuje kyselina mlie\u010dna<\/strong>. Kyselina mlie\u010dna men\u00ed pH v bunk\u00e1ch, po smrti a rozpade bunky ovplyv\u0148uje pH cel\u00fdch tkan\u00edv. \u010eal\u0161\u00edm d\u00f4sledkom hypoxie je strata balansu medzi reakt\u00edvnymi kysl\u00edkov\u00fdmi formami a vo\u013enymi radik\u00e1lmi,<\/strong> \u010d\u00edm vznik\u00e1 oxida\u010dn\u00fd stres<\/strong>. Kysl\u00edk v organizme napom\u00e1ha udr\u017eiava\u0165 zdrav\u00fa antioxida\u010dn\u00fa rovnov\u00e1hu. <\/p>\n\n\n\n

Okrem poklesu parci\u00e1lneho tlaku kysl\u00edka v na\u0161ich tkaniv\u00e1ch, sa s vekom zni\u017euje aj kapacita p\u013e\u00fac, doch\u00e1dza k tvrdnutiu a zablokovaniu tepien a mal\u00fdch ciev, \u010do v\u00fdrazne ovplyv\u0148uje schopnos\u0165 pln\u00e9ho z\u00e1sobovania tkan\u00edv kysl\u00edkom.<\/strong> S vekom takisto kles\u00e1 mno\u017estvo vody v na\u0161om organizme.<\/strong> Do 20-teho roku \u017eivota tvor\u00ed voda a\u017e 80% organizmu, zatial \u010do mno\u017estvo vody v tele 60-ro\u010dn\u00e9ho \u010dloveka je u\u017e len okolo 50%. T\u00fdm, \u017ee m\u00e1 organizmus menej vody sa krv zhus\u0165uje. Hustej\u0161ia krv u\u017e nedok\u00e1\u017ee prejis\u0165 aj cez tie najten\u0161ie krvn\u00e9 vl\u00e1so\u010dnice a nedok\u00e1\u017ee tak plne z\u00e1sobi\u0165 aj tie najvzdialenej\u0161ie bunky kysl\u00edkom. <\/strong><\/p>\n\n\n\n

Starnutiu sa nevyhne nikto z n\u00e1s, alebo \u00e1no?<\/h2>\n\n\n\n

V ned\u00e1vno publikovanom v\u00fdskume sa t\u00edm izraelsk\u00fdch vedcov zameral na dva k\u013e\u00fa\u010dov\u00e9 ukazovatele starnutia: na d\u013a\u017eku telom\u00e9rov (koncov\u00e9 \u010dasti hromoz\u00f3mov DNA) a na odstra\u0148ovanie starn\u00facich a nefunk\u010dn\u00fdch buniek z organizmu. „Dnes sa skracovanie telom\u00e9rov pova\u017euje za \u201esv\u00e4t\u00fd gr\u00e1l\u201c biol\u00f3gie starnutia”,<\/strong> povedal Efrati. Telom\u00e9ry toti\u017e neust\u00e1le chr\u00e1nia na\u0161u DNA pri replik\u00e1cii buniek, pri\u010dom sa skracuj\u00fa. Akon\u00e1hle sa telom\u00e9r skr\u00e1ti na ur\u010dit\u00fa d\u013a\u017eku, bunka sa u\u017e \u010falej nem\u00f4\u017ee replikova\u0165, starne a prest\u00e1va fungova\u0165. N\u00e1sledne sa tak\u00e9to bunky hromadia v organizme.<\/p>\n\n\n\n

P\u00e4\u0165 dn\u00ed v t\u00fd\u017edni po dobu troch mesiacov bolo 35 zdrav\u00fdch dospel\u00fdch nad 64 rokov umiest\u0148ovan\u00fdch do hyperbarickej kysl\u00edkovej komory (HBO) na dobu 90 min\u00fat. Po troch mesiacoch vedci zistili, \u017ee vo v\u00e4\u010d\u0161ine pr\u00edpadov pravideln\u00fdm zvy\u0161ovan\u00edm parci\u00e1lneho tlaku kysl\u00edka v tkaniv\u00e1ch d\u013a\u017eka telom\u00e9rov ostala zachovan\u00e1 a dokonca v niektor\u00fdch pr\u00edpadoch sa telom\u00e9ry zv\u00e4\u010d\u0161ili. Takisto do\u0161lo a\u017e k 37% zn\u00ed\u017eeniu nahromaden\u00fdch nefunguj\u00facich buniek. (Publikovan\u00e9 v Aging journal 18. novembra).<\/strong><\/p>\n\n\n\n

Chronick\u00e9 ochorenia ako hlavn\u00e1 pr\u00ed\u010dina \u00famrtnosti \u013eud\u00ed na svete a hypoxia<\/h2>\n\n\n\n

Hypoxia je dnes s\u00fa\u010das\u0165ou mnoh\u00fdch zdravotn\u00fdch probl\u00e9mov a chorobn\u00fdch stavov, predov\u0161etk\u00fdm t\u00fdch chronick\u00fdch. Alarmuj\u00face je, \u017ee dnes trp\u00ed ka\u017ed\u00ed piati \u010dlovek na svete na aspo\u0148 jedno chronick\u00e9 ochorenie. A a\u017e 50% z t\u00fdchto \u013eud\u00ed trp\u00ed na \u010fal\u0161ie jedno chronick\u00e9 ochorenie. <\/strong>Svetov\u00e1 zdravotn\u00edcka organiz\u00e1cia definuje chronick\u00e9 ochorenie ako ochorenie s dlh\u00fdm trvan\u00edm a v\u0161eobecne pomalou progresiou. Pri star\u0161\u00edch \u013eu\u010foch s\u00fa \u0161tatistiky naozaj hroziv\u00e9 – a\u017e 80% \u013eud\u00ed nad 65 rokov trp\u00ed na aspo\u0148 jedno chronick\u00e9 ochorenie. 68% \u013eud\u00ed nad 65 rokov trp\u00ed na dve a viac chronick\u00fdch ochoren\u00ed.<\/strong><\/p>\n\n\n\n

Chronick\u00e9 ochorenia s\u00fa dnes hlavnou pr\u00ed\u010dinou chorobnosti a \u00famrtnosti dospel\u00fdch \u013eud\u00ed na celom svete<\/strong>. Patria medzi ne diabetes, sp\u00e1nkov\u00e9 apnoe, rakovina, m\u0155tvica, mozgov\u00e1 por\u00e1\u017eka, stukovatel\u00e1 pe\u010de\u0148, neplodnos\u0165, men\u0161trua\u010dn\u00e9 bolesti, akn\u00e9, ale m\u00f4\u017ee aj za celkov\u00e9 zl\u00e9 hojenie r\u00e1n<\/strong>. Nov\u00e9 vedeck\u00e9 \u0161t\u00fadie zistili ne\u00fa\u010dinnos\u0165 chemoterapie pri n\u00e1doroch s hypoxiou<\/strong>. Pri hypoxi\u00ed je teda ak\u00e1ko\u013evek lie\u010dba v\u00fdrazne menej \u00fa\u010dinn\u00e1.<\/p>\n\n\n\n

Ako sa d\u00e1 jednoducho zbavi\u0165 hypoxie a z\u00e1rove\u0148 omladn\u00fa\u0165 o 10 rokov?<\/h2>\n\n\n\n

KAQUN pon\u00faka celosvetovo unik\u00e1tnu a efekt\u00edvnu formu prevencie pred hypoxiou. <\/strong>Potvrden\u00e9 viac ako 20 rokmi klinick\u00fdmi a vedeck\u00fdmi v\u00fdskumami. U\u017eit\u00edm kysl\u00edkovej vody KAQUN <\/a>dok\u00e1\u017eete zv\u00fd\u0161i\u0165 parci\u00e1lny tlak v tkaniv\u00e1ch a\u017e o 22% a pod\u013ea prilo\u017een\u00e9ho grafu sa tak na osy x (vek) posuniete o 10 rokov dozadu!<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Hypoxia m\u00f4\u017ee postihn\u00fa\u0165 ka\u017ed\u00e9ho z n\u00e1s v akomko\u013evek veku. Je to pr\u00e1ve hypoxia, ktor\u00e1 je s\u00fa\u010das\u0165ou v\u00e4\u010d\u0161iny chronick\u00fdch ochoren\u00ed. Viete ako sa pred hypoxiou br\u00e1ni\u0165?<\/p>\n","protected":false},"author":3,"featured_media":12002,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"class_list":["post-4039","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kvalita-zivota-a-zdravia"],"yoast_head":"\n\u010co n\u00e1m zabudli poveda\u0165: Hypoxia najlep\u0161\u00ed priate\u013e rakoviny<\/title>\n<meta name=\"description\" content=\"Ka\u017edodenn\u00fd r\u00fdchly \u017eivotn\u00fd \u0161t\u00fdl, zl\u00e1 \u017eivotospr\u00e1va, dennej d\u00e1vky tekut\u00edn, nedostatok pohybu a ka\u017edodenn\u00fd stres. Zme\u0148te to. 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